| Identification | Back Directory | [Name]
PTIO | [CAS]
18390-00-6 | [Synonyms]
PTIO
PTIO,98%
PTIO
2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE
2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL
PTIO (2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL)
4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-2-PHENYL-1H-IMIDAZOL-1-YLOXY-1-OXIDE
[[2-Phenyl-4,4,5,5-tetramethyl-2-imidazoline 3-oxide]-1-yloxy]radical
[[4,4,5,5-Tetramethyl-2-phenyl-2-imidazoline 3-oxide]-1-yloxy]radical
[[(2-Phenyl-3-oxylato-4,4,5,5-tetramethyl-1H-imidazole-3-ium)-1-yl]oxy]radical
[(4,5-Dihydro-2-phenyl-4,4,5,5-tetramethyl-1H-imidazole-3-oxide)-1-yloxy]radical
[(2-Phenyl-4,4,5,5-tetramethyl-3-oxylato-4,5-dihydro-1H-imidazole-3-ium)-1-yloxy]radical
2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl)[stablefreeradicalreagentforthesimultaneousdetermin
4,5-Dihydro-4,4,5,5-tetramethyl-2-phenyl-1H-imidazol-1-yloxy-1-oxide
2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl
(=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]
PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]
PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere] | [Molecular Formula]
C13H17N2O2 * | [MDL Number]
MFCD00059929 | [MOL File]
18390-00-6.mol | [Molecular Weight]
233.29 |
| Chemical Properties | Back Directory | [Appearance]
blue crystals | [Melting point ]
approximate 86℃ | [storage temp. ]
2-8°C
| [solubility ]
soluble in Methanol | [form ]
Dark blue solid | [color ]
Blue to Dark blue | [InChI]
InChI=1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3 | [InChIKey]
DYUUGILMVYJEHY-UHFFFAOYSA-N | [SMILES]
C1(C)(C)N([O])C(C2C=CC=CC=2)=[N+]([O-])C1(C)C |^1:4| |
| Hazard Information | Back Directory | [Chemical Properties]
blue crystals | [Description]
PTIO is an oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. It can be used to assay nitric oxide production when examining nitric oxide synthase inhibitory activity. | [Uses]
2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger. | [Uses]
PTIO is a nitric oxide (NO) radical scavenger used to inhibit physiological effects of NO. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 90, p. 1078, 1968 DOI: 10.1021/ja01006a053 | [General Description]
Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors. | [Biochem/physiol Actions]
Product does not compete with ATP. | [References]
[1] SARA GOLDSTEIN Amram S Angelo Russo. Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.[J]. The Journal of Biological Chemistry, 2003, 278 51: 50949-50955. DOI: 10.1074/jbc.m308317200
[2] N NAKATSUBO. Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors.[J]. Biological & pharmaceutical bulletin, 1998, 21 12: 1247-1250. DOI: 10.1248/bpb.21.1247 |
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