| Chemical Properties | Back Directory | [Boiling point ]
716.8±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
14.45±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
DBCO-C2-alcohol is a linker containing a DBCO moiety and a terminal primary hydroxyl group. DBCO group can react with azides in copper-free Click Chemistry reactions. The hydroxyl can react with a variety of functional groups. | [Uses]
DBCO-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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