| Identification | Back Directory | [Name]
(2S)-4-[5-[[[4-(4-Chloro-2-thienyl)-5-[[(2R)-2-methyl-1-pyrrolidinyl]methyl]-2-thiazolyl]amino]carbonyl]-2-pyrazinyl]-2-methyl-1-piperazinepropanoic acid | [CAS]
1839583-42-4 | [Synonyms]
ASP8302
(2S)-4-[5-[[[4-(4-Chloro-2-thienyl)-5-[[(2R)-2-methyl-1-pyrrolidinyl]methyl]-2-thiazolyl]amino]carbonyl]-2-pyrazinyl]-2-methyl-1-piperazinepropanoic acid | [Molecular Formula]
C26H32ClN7O3S2 | [MOL File]
1839583-42-4.mol | [Molecular Weight]
590.16 |
| Hazard Information | Back Directory | [Uses]
ASP8302 is a positive allosteric modulator of muscarinic M3 Receptor. ASP8302 improves voiding efficiency and reduced residual urine volume in two voiding dysfunction models. ASP8302 can be used for research of underactive bladder[1][2]. | [IC 50]
mAChR3 | [References]
[1] Okimoto R, et al. Potentiation of Muscarinic M3?Receptor Activation through a New Allosteric Site with a Novel Positive Allosteric Modulator ASP8302. J Pharmacol Exp Ther. 2021 Oct;379(1):64-73. DOI:10.1124/jpet.121.000709
[2] Okimoto R, et al. Muscarinic M3?positive allosteric modulator ASP8302 enhances bladder contraction and improves voiding dysfunction in rats. Low Urin Tract Symptoms. 2022 Jul;14(4):289-300. DOI:10.1111/luts.12430 |
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