| Identification | Back Directory | [Name]
Imidodicarbonic acid, 2-[6-nitro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)-5-isoquinolinyl]-, 1,3-bis(1,1-dimethylethyl) ester | [CAS]
1841444-11-8 | [Synonyms]
MK-6240 Precursor
Imidodicarbonic acid, 2-[6-nitro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)-5-isoquinolinyl]-, 1,3-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C26H27N5O6 | [MOL File]
1841444-11-8.mol | [Molecular Weight]
505.53 |
| Chemical Properties | Back Directory | [Boiling point ]
610.9±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.69±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MK-6240 Precursor (6e) is the synthetic precursor of (18)[F]-MK-6240. (18)F]-MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs[1]. | [References]
[1] 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89. DOI:10.1021/acs.jmedchem.6b00166 |
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YantaiBio
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13758194781 |
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