| Identification | Back Directory | [Name]
SR 142948 | [CAS]
184162-64-9 | [Synonyms]
SR 142948
LWULHXVBLMWCHO-UHFFFAOYSA-N
inhibit,HT 29,Neurotensin Receptor,SR 142948,CHO cells,SR142948,SR-142948,dopamine,neurotensin,Inhibitor,psychotic disorders
2-[(5-(2,6-DIMETHOXY-PHENYL)-1-(4-[(3-DIMETHYLAMINO-PROPYL)-METHYL-CARBAMOYL]-2-ISOPROPYL-PHENYL)-1H-PYRAZOLE-3-CARBONYL)-AMINO]-ADAMANTANE-2-CARBOXYLIC ACID
2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID
TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID, 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]- | [Molecular Formula]
C39H51N5O6 | [MDL Number]
MFCD03106493 | [MOL File]
184162-64-9.mol | [Molecular Weight]
685.852 |
| Chemical Properties | Back Directory | [Boiling point ]
824.7±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 75 mM in DMSO and to 25 mM in water | [form ]
Powder | [pka]
3.28±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SR 142948 is an antagonist of NT1/NT2 receptors inhibiting bile acid secretion. Neurotensin receptor antagonist. | [Definition]
ChEBI: 2-[[[5-(2,6-dimethoxyphenyl)-1-[4-[[3-(dimethylamino)propyl-methylamino]-oxomethyl]-2-propan-2-ylphenyl]-3-pyrazolyl]-oxomethyl]amino]-2-adamantanecarboxylic acid is a N-acyl-amino acid. | [Biological Activity]
Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC 50 = 0.32 - 3.96 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo . | [storage]
Store at +4°C |
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Energy Chemical
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