| Identification | Back Directory | [Name]
PI3Kβ and δ inhibitor 20a | [CAS]
1842380-77-1 | [Synonyms]
PI3K-IN-6
PI3Kβ and δ inhibitor 20a
4(3H)-Quinazolinone, 8-chloro-2-[(1S)-1-[(2,6-diamino-5-chloro-4-pyrimidinyl)amino]ethyl]-6-fluoro-3-(1H-pyrazol-3-yl)- | [Molecular Formula]
C17H14Cl2FN9O | [MDL Number]
MFCD30747877 | [MOL File]
1842380-77-1.mol | [Molecular Weight]
450.26 |
| Chemical Properties | Back Directory | [Boiling point ]
836.1±75.0 °C(Predicted) | [density ]
1.85±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.27±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1]. | [IC 50]
PI3Kβ: 7.8 nM (IC50); PI3Kδ: 5.3 nM (IC50); PI3Kα: 850 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Che DOI:10.1021/acs.jmedchem.6b01821 |
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