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1844889-12-8

1844889-12-8 Structure

1844889-12-8 Structure
IdentificationBack Directory
[Name]

3,5-Pyridinedicarboxylic acid, 1-benzoyl-1,4-dihydro-4-(3-methoxyphenyl)-, 3,5-diethyl ester
[CAS]

1844889-12-8
[Synonyms]

MC3138
3,5-Pyridinedicarboxylic acid, 1-benzoyl-1,4-dihydro-4-(3-methoxyphenyl)-, 3,5-diethyl ester
[Molecular Formula]

C25H25NO6
[MOL File]

1844889-12-8.mol
[Molecular Weight]

435.47
Chemical PropertiesBack Directory
[Boiling point ]

574.4±50.0 °C(Predicted)
[density ]

1.231±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

-4.50±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1].
[References]

[1] Hu T, et al. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600. DOI:10.1053/j.gastro.2021.06.045
1844889-12-8 suppliers list
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