Identification | Back Directory | [Name]
3,5-Pyridinedicarboxylic acid, 1-benzoyl-1,4-dihydro-4-(3-methoxyphenyl)-, 3,5-diethyl ester | [CAS]
1844889-12-8 | [Synonyms]
MC3138 3,5-Pyridinedicarboxylic acid, 1-benzoyl-1,4-dihydro-4-(3-methoxyphenyl)-, 3,5-diethyl ester | [Molecular Formula]
C25H25NO6 | [MOL File]
1844889-12-8.mol | [Molecular Weight]
435.47 |
Chemical Properties | Back Directory | [Boiling point ]
574.4±50.0 °C(Predicted) | [density ]
1.231±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-4.50±0.70(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1]. | [References]
[1] Hu T, et al. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600. DOI:10.1053/j.gastro.2021.06.045 |
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