| Chemical Properties | Back Directory | [Boiling point ]
591.2±39.0 °C(Predicted) | [density ]
1.01±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);19.42(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);19.42(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.27(Max Conc. mM) | [form ]
A crystalline solid | [pka]
12.49±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
DMPAC-Chol is a cationic cholesterol derivative that has been used in liposome formation for gene transfection. Liposomes containing DMPAC-chol bind to DNA in a band shift assay and protect against serum nuclease degradation of DNA when used at lipsome:DNA ratios ranging from 2.5:1 to 10:1 w/w. DMPAC-Chol-containing liposomes also reduce viability of HepG2 cells by 63% when used at a concentration of 37.5 μg/ml. | [Uses]
DMPAC-Chol (Chol-T) is used for liposome formation. DMPAC-Chol (Chol-T) liposomes exhibits great transfection effciencies[1]. | [storage]
Store at -20°C | [References]
[1] Neermala Kisoon, et al. A novel cationic cholesterol derivative, its formulation into liposomes, and the efficient transfection of the transformed human cell lines HepG2 and HeLa. Drug Deliv. 2002 Jul-Sep;9(3):161-7. DOI:10.1080/15227950290097598 |
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