| Identification | Back Directory | [Name]
Carabersat | [CAS]
184653-84-7 | [Synonyms]
Carabersat
Benzamide, N-[(3R,4S)-6-acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-4-fluoro- | [Molecular Formula]
C20H20FNO4 | [MDL Number]
MFCD00944470 | [MOL File]
184653-84-7.mol | [Molecular Weight]
357.38 |
| Chemical Properties | Back Directory | [Boiling point ]
559.3±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.05±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Carabersat is a potent anticonvulsant agent. | [in vivo]
Carabersat (5b) significantly elevates anticonvulsant activity in mice[1]. | [References]
[1] Wai N. Chan, et al. Synthesis of Novel trans-4-(Substituted-benzamido)-3,4-dihydro-2H-benzo[b]pyran-3-ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile. J. Med. Chem., 1996, 39 (23), pp 4537-4539.
[2] Herdon H, et al. The novel anticonvulsant SB 204269 binds to a stereospecific site in the mouse brain. Eur J Pharmacol. 1996 Oct 31;314(3):R7-8. DOI:10.1016/s0014-2999(96)00737-6
[3] Caeser M, et al. Lack of effect of the novel anticonvulsant SB-204269 on voltage-dependent currents in neurones cultured from rat hippocampus. Neurosci Lett. 1999 Aug 13;271(1):57-60. DOI:10.1016/s0304-3940(99)00514-5
[4] Crespi F, et al. SB-204269 SmithKline Beecham. IDrugs. 1998 Sep;1(5):595-8. PMID:18465599 |
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