| Identification | Back Directory | [Name]
PI3K/mTOR Inhibitor-2 | [CAS]
1848242-58-9 | [Synonyms]
PI3K/mTOR Inhibitor-2
Benzenesulfonamide, N-[5-(3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluoro- | [Molecular Formula]
C20H13ClF2N4O4S | [MDL Number]
MFCD31813651 | [MOL File]
1848242-58-9.mol | [Molecular Weight]
478.86 |
| Chemical Properties | Back Directory | [Boiling point ]
609.4±65.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.38±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1]. | [IC 50]
PI3Kα: 3.4 nM (IC50); PI3Kβ: 34 nM (IC50); PI3Kδ: 16 nM (IC50); PI3Kγ: 1 nM (IC50); mTOR: 4.7 nM (IC50) | [References]
[1] Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261. DOI:10.1021/acsmedchemlett.8b00002 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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