| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-β-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]- | [CAS]
1848959-10-3 | [Synonyms]
TAS4464
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-β-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]- | [Molecular Formula]
C21H23FN6O6S | [MDL Number]
MFCD32067967 | [MOL File]
1848959-10-3.mol | [Molecular Weight]
506.51 |
| Chemical Properties | Back Directory | [Boiling point ]
838.3±75.0 °C(Predicted) | [density ]
1.66±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (246.79 mM) | [form ]
Solid | [pka]
10.81±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1]. | [storage]
Store at -20°C | [References]
[1] Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15. DOI:10.1158/1535-7163.MCT-18-0644 |
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