| Identification | Back Directory | [Name]
TAS4464 hydrochloride | [CAS]
1848959-11-4 | [Synonyms]
TAS4464 HCl
TAS4464 hydrochloride
TAS-4464,TAS 4464,TAS4464,NEDD8-activating Enzyme,inhibit,Inhibitor,NAE,TAS-4464 hydrochloride,TAS4464 hydrochloride | [Molecular Formula]
C21H24ClFN6O6S | [MDL Number]
MFCD32067968 | [MOL File]
1848959-11-4.mol | [Molecular Weight]
542.97 |
| Hazard Information | Back Directory | [Uses]
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1]. TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15. DOI:10.1158/1535-7163.MCT-18-0644 |
|
|