| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤10mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide | [form ]
crystalline solid |
| Hazard Information | Back Directory | [Description]
Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 μM). It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells. | [Uses]
Se-Aspirin is a hybrid of selenium and a nonsteroidal anti-inflammatory drug that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC50 = 3.4 μM). It can inhibit the cell cycle in G1 and G2/M phases and induce apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin is reported to cause an increase in intracellular reactive oxygen species levels in CRC cells.[Cayman Chemical] | [storage]
Store at -20°C | [References]
[1] plano d, karelia d n, pandey m k, et al. design, synthesis, and biological evaluation of novel selenium (se-nsaid) molecules as anticancer agents[j]. journal of medicinal chemistry, 2016, 59(5): 1946-1959. |
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| Company Name: |
Boao Pike
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| Tel: |
010-57798038 15652371397 |
| Website: |
www.biopike.cn |
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