| Identification | Back Directory | [Name]
PREGNENOLONE SULFATE SODIUM SALT | [CAS]
1852-38-6 | [Synonyms]
Pregnenolone 3-Sulfate
PREGNENOLONE SULFATE SODIUM
SodiuM Pregnenolone-d4 Sulfate
5-Pregnen-3β-ol-20-one sulfate
Pregnenolone sulphate Na+ salt
PREGNENOLONE SULFATE SODIUM SALT
PREGNENOLONE SULPHATE, SODIUM SALT
Pregnenolone-3-sulfate SodiuM Salt
3-Hydroxypregn-5-en-20-one sulfate
Pregnenolone monosulfate sodium salt
3β-Hydroxy-5-pregnen-20-one 3-sulfate
5-pregnen-3B-ol-20-one sulfate sodium
5-PREGNEN-3BETA-OL-20-ONE3-SULFATE SODIUM
5-PREGNEN-3B-OL-20-ONE SULFATE SODIUM SALT
5-PREGNEN-3BETA-OL-20-ONE SULFATE SODIUM SALT
3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT
(3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
5-Pregnen-3-beta-ol-2o-one sulphate,sodium salt
5-PREGNEN-3-BETA-OL-20-ONE SULPHATE, SODIUM SALT
3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT
3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt
3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT
PREGNENOLONE SULFATE SODIUM SALT 5-PREGN EN-3B-OL-20-ON
3β-Hydroxy-5-pregnen-20-one 3-sulfate, 3-Hydroxypregn-5-en-20-one sulfate, 5-Pregnen-3β-ol-20-one sulfate | [Molecular Formula]
C21H31NaO5S | [MDL Number]
MFCD00056177 | [MOL File]
1852-38-6.mol | [Molecular Weight]
418.52 |
| Chemical Properties | Back Directory | [Melting point ]
192 °C(lit.)
| [storage temp. ]
Store at -20°C | [solubility ]
methanol and water: 1.93 mg/mL
| [form ]
A crystalline solid | [color ]
White to off-white | [InChIKey]
ABFNHVDDMHKJKK-WRHGONFGSA-N | [SMILES]
[Na].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O)OS(O)(=O)=O |
| Hazard Information | Back Directory | [Description]
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3). | [Uses]
Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3). | [Uses]
Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor. | [Biochem/physiol Actions]
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway. | [in vivo]
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1]. | [IC 50]
CB1; Human Endogenous Metabolite | [storage]
Store at +4°C | [References]
[1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH David H F Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL Oliver G R Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237 |
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