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185220-03-5

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185220-03-5 Structure

185220-03-5 Structure
IdentificationBack Directory
[Name]

PNU 142721
[CAS]

185220-03-5
[Synonyms]

PNU 142721
6-chloro-2-[(1S)-1-furo[2,3-c]pyridin-5-ylethyl]sulfanylpyrimidin-4-amine
4-Pyrimidinamine, 6-chloro-2-[[(1S)-1-furo[2,3-c]pyridin-5-ylethyl]thio]-
[Molecular Formula]

C13H11ClN4OS
[MDL Number]

MFCD00952540
[MOL File]

185220-03-5.mol
[Molecular Weight]

306.77
Chemical PropertiesBack Directory
[Melting point ]

169-170.5 °C
[Boiling point ]

504.0±50.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[pka]

3.28±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

PNU-142721 is a reverse transcriptase inhibitor and PXR agonist that effectively inhibits various type I HIV variants[1].
[References]

[1] Cheng Y, et al. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase‐targeted anti‐HIV drug PNU‐142721[J]. Protein Science, 2011, 20(10): 1713-1719. DOI:10.1002/pro.706
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