| Identification | Back Directory | [Name]
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE | [CAS]
185259-85-2 | [Synonyms]
GR 46611
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE
3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide
2-Propenamide, 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]- | [Molecular Formula]
C23H27N3O2 | [MDL Number]
MFCD00953517 | [MOL File]
185259-85-2.mol | [Molecular Weight]
377.48 |
| Chemical Properties | Back Directory | [Boiling point ]
645.9±55.0 °C(Predicted) | [density ]
1.168 | [storage temp. ]
2-8°C | [solubility ]
DMSO: 28 mg/mL, soluble | [form ]
solid | [pka]
14.51±0.46(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
GR 46611is a 5-HT1D agonist. | [Definition]
ChEBI: 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide is a member of tryptamines. | [Biological Activity]
5-HT 1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT 1D receptor ligands. | [in vivo]
GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig[4].
| Animal Model: | Dravet syndrome (DS) mice[1] | | Dosage: | 0.01, 0.1 and 1 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Improved survival relative to vehicle treated controls with 89% surviving rate. |
| [IC 50]
5-HT1D Receptor |
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