| Identification | Back Directory | [Name]
Benzenesulfonamide, 5-bromo-N-(1-ethyl-1,2-dihydro-2-oxobenz[cd]indol-6-yl)-2-methoxy- | [CAS]
1853988-48-3 | [Synonyms]
Y02224
Y-02224
Y 02224
Benzenesulfonamide, 5-bromo-N-(1-ethyl-1,2-dihydro-2-oxobenz[cd]indol-6-yl)-2-methoxy- | [Molecular Formula]
C20H17BrN2O4S | [MOL File]
1853988-48-3.mol | [Molecular Weight]
461.33 |
| Hazard Information | Back Directory | [Description]
Y02224 is a BET inhibitor which exhibited reasonable antiproliferative effect on leukemia cells. | [Uses]
Y02224 is a potent BRD4 inhibitor and exhibits reasonable antiproliferative effect on leukemia cells.Y02224 has the potential for? CRPC research[1]. | [References]
[1] Maofeng Zhang, et al. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). J Med Chem. 2018 Apr 12;61(7):3037-3058. DOI:10.1021/acs.jmedchem.8b00103 |
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