| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-5-(trifluoromethyl)- | [CAS]
1854086-05-7 | [Synonyms]
Trifluoromethyl-tubercidin
7-β-D-Ribofuranosyl-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-5-(trifluoromethyl)- | [Molecular Formula]
C12H13F3N4O4 | [MOL File]
1854086-05-7.mol | [Molecular Weight]
334.25 |
| Chemical Properties | Back Directory | [Boiling point ]
623.7±55.0 °C(Predicted) | [density ]
1.96±0.1 g/cm3(Predicted) | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [pka]
12.34±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Trifluoromethyl-tubercidin (TFMT) is a 2'-O-ribose methyltransferase 1 (MTr1) inhibitor through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication[1]. | [References]
[1] Yuta Tsukamoto, et al. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023 Feb 10;379(6632):586-591. DOI:10.1126/science.add0875 |
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