| Identification | Back Directory | [Name]
(R)-2-PROPYLOCTANOIC ACID | [CAS]
185517-21-9 | [Synonyms]
Cereact
Proglia
ONO 2506
ONO 2506PO
arundic acid
R-(-)-Arundic Acid
Arundic acid [INN]
(R)-2-PROPYLOCTANOIC ACID
(-)-(2R)-2-Propyloctanoic acid
Octanoic acid, 2-propyl-, (2R)- | [Molecular Formula]
C11H22O2 | [MDL Number]
MFCD08458423 | [MOL File]
185517-21-9.mol | [Molecular Weight]
186.29 |
| Chemical Properties | Back Directory | [Boiling point ]
289℃ | [density ]
0.908 | [Fp ]
154℃ | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly) | [form ]
Oil | [pka]
4.82±0.40(Predicted) | [color ]
Clear Colorless to Clear Pale Yellow |
| Hazard Information | Back Directory | [Description]
Arundic acid is an inhibitor of astrocyte activation. It reduces increases in brain glial fibrillary acid protein (GFAP) and S100β levels, markers of astrocyte activation, in a rat model of permanent focal ischemia induced by middle cerebral artery occlusion when administered at a dose of 10 mg/kg. Arundic acid (3 and 10 mg/kg) decreases the number of TUNEL-positive neurons, reduces infarct size, and improves motor performance in the rotarod test in the same model. It also reduces descent time and time to turn in a pole test, indicating reversal of motor deficits, in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 30 mg/kg. | [Chemical Properties]
Clear Colorless Oil | [Uses]
An astrocyte modulating agent, in acute ischemic stroke. | [storage]
Store at -20°C | [References]
[1] N. TATEISHI. Astrocytic Activation and Delayed Infarct Expansion after Permanent Focal Ischemia in Rats. Part II: Suppression of Astrocytic Activation by a Novel Agent (R)-(?)-2-propyloctanoic acid (ONO-2506) Leads to Mitigation of Delayed Infarct Expansion and Early Improvement of Neurologic Deficits[J]. Journal of Cerebral Blood Flow & Metabolism, 2002, 26 1: 723-734. DOI: 10.1097/00004647-200206000-00011
[2] HIROYUKI KATO . Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice[J]. Brain Research, 2004, 1030 1: Pages 66-73. DOI: 10.1016/j.brainres.2004.09.046 |
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Shanghai GL Peptide Ltd.
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+86-21-61263340; 17609490614 13764994101 |
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https://www.chemicalbook.com/supplier/10480342/ |
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