| Identification | Back Directory | [Name]
(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE | [CAS]
185517-74-2 | [Synonyms]
S-PAI
TV 1022
TVP 1022
(S)-Rasagiline
(S)-RASAGILINE;S-PAI
TVP1022 >=98% (HPLC)
S-(-)-N-Propargyl-1-aminoindan
(S)-N-(2-Propynyl)-2,3-dihydroinden-1-aMine
(1S)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine
(1S)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
(1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine
(S)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine
1H-Inden-1-amine, 2,3-dihydro-N-2-propyn-1-yl-, (1S)-
(S)-2,3-DIHYDRO-N-METHYL-N-2-PROPYNYL-1H-INDEN-1-AMINE | [Molecular Formula]
C12H13N | [MDL Number]
MFCD07367856 | [MOL File]
185517-74-2.mol | [Molecular Weight]
171.24 |
| Chemical Properties | Back Directory | [Boiling point ]
305.5±30.0 °C(Predicted) | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
6.95±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
TVP1022the S-isomer of rasagilinean anti-Parkinson drugappears to have the same neuroprotective activity as the R-isomerbut is 1000-fold less active as an MAO-B inhibitor. TVP1022 a neuroprotective and cytoprotective moleculeis also cardioprotective in r at models. Its activity is believed to involve stabilization of mitochondrial membrane potentialinduction of Bcl-2 and activation of the PKC signalling pathwayenhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β. | [storage]
Store at -20°C | [References]
[1] M B Youdim, et al. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132(2):500-6. DOI:10.1038/sj.bjp.0703826 |
|
|