| Identification | Back Directory | [Name]
7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 5-[4-[2,6-difluoro-4-(2-methoxyethoxy)phenyl]-1-piperazinyl]-3,6-dihydro-3-methyl- | [CAS]
1858179-75-5 | [Synonyms]
basroparib
Basroparib (STP1002)
5-[4-[2,6-difluoro-4-(2-methoxyethoxy)phenyl]-1-piperazinyl]-3,6-dihydro-3-methyl-7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one
7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 5-[4-[2,6-difluoro-4-(2-methoxyethoxy)phenyl]-1-piperazinyl]-3,6-dihydro-3-methyl- | [Molecular Formula]
C18H21F2N7O3 | [MOL File]
1858179-75-5.mol | [Molecular Weight]
421.4 |
| Chemical Properties | Back Directory | [Boiling point ]
595.6±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.09±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Basroparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 5.8 nM for TNKS1, exhibiting antitumor activity[1][2]. | [References]
[1] International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.
[2] Bai YR, et al. The recent advance and prospect of poly(ADP-ribose) polymerase inhibitors for the treatment of cancer. Med Res Rev. 2024 Aug 24. DOI:10.1002/med.22069 |
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Wuhan Topule
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