| Identification | Back Directory | [Name]
ROC-325 | [CAS]
1859141-26-6 | [Synonyms]
ROC-325
ROC325;ROC 325
9H-Thioxanthen-9-one, 1-[[2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]methylamino]ethyl]amino]-4-methyl- | [Molecular Formula]
C28H27ClN4OS | [MDL Number]
MFCD31619252 | [MOL File]
1859141-26-6.mol | [Molecular Weight]
503.06 |
| Chemical Properties | Back Directory | [Boiling point ]
726.0±60.0 °C(Predicted) | [density ]
1.344±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: 10 mg/ml; DMF: slightly soluble; DMSO: slightly soluble; Ethanol: slightly soluble | [form ]
A solid | [pka]
8.36±0.50(Predicted) | [color ]
Light yellow to orange | [InChIKey]
HXUYKEGAEIYPKY-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C=CC=C2)SC2=C1C(NCCN(CCNC1=C3C(=NC=C1)C=C(Cl)C=C3)C)=CC=C2C |
| Hazard Information | Back Directory | [Uses]
ROC 325, is a novel inhibitor of autophagy. It triggers an increase in cathepsin D (CTSD) levels. | [in vivo]
Oral administration of ROC-325 (25 mg/kg, 40 mg/kg, 50 mg/kg,) to mice bearing 786-0 RCC xenografts is well tolerated, significantly more effective at inhibiting tumor progression than Hydroxychloroquine, and inhibits autophagy in vivo[1]. | [storage]
Store at -20°C |
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