| Identification | Back Directory | [Name]
TOFIMILAST | [CAS]
185954-27-2 | [Synonyms]
366
CP 325
CP-325
CP325366
CP-325366
CP 325366
TOFIMILAST | [Molecular Formula]
C18H21N5S | [MDL Number]
MFCD00954272 | [MOL File]
185954-27-2.mol | [Molecular Weight]
339.46 |
| Chemical Properties | Back Directory | [Melting point ]
125-126 °C(Solv: ethyl ether (60-29-7)) | [Boiling point ]
589.4±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [pka]
1.76±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Tofimilast is an inhibitor of Phosphodiesterase 4 (PDE4) with an IC50 of 0.14 μM. Tofimilast exerts its anti-inflammatory effects by inhibiting the activity of PDE4, thereby increasing intracellular levels of cAMP[1]. | [Definition]
ChEBI: Tofimilast is a triazolopyridine. | [IC 50]
PDE4: 0.14 μM (IC50) | [References]
[1] Duplantier AJ, et al. SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. J Med Chem. 2007 Jan 25;50(2):344-9. DOI:10.1021/jm060904g |
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