| Identification | Back Directory | [Name]
3-Pyridineethanol, 5-(4-chlorophenyl)-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)- | [CAS]
1859978-72-5 | [Synonyms]
WX-081
3-Pyridineethanol, 5-(4-chlorophenyl)-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)- | [Molecular Formula]
C34H33ClN2O2 | [MOL File]
1859978-72-5.mol | [Molecular Weight]
537.1 |
| Hazard Information | Back Directory | [Uses]
Fudapirine, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. Fudapirine exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. Fudapirine also inhibits hERG channel with the IC50 of 1.89 μM. | [References]
[1] Zhigang Huang, et al. Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. Bioorg Med Chem Lett.?2022 Sep 1;71:128824. DOI:10.1016/j.bmcl.2022.128824 |
|
|