| Identification | Back Directory | [Name]
2-amino-5-(2-fluorophenyl)-4-methyl-1H-pyrrole-3-carbonitrile | [CAS]
186033-14-7 | [Synonyms]
2-amino-5-(2-fluorophenyl)-4-methyl-1H-pyrrole-3-carbonitrile
1H-Pyrrole-3-carbonitrile, 2-amino-5-(2-fluorophenyl)-4-methyl- | [Molecular Formula]
C12H10FN3 | [MOL File]
186033-14-7.mol | [Molecular Weight]
215.23 |
| Hazard Information | Back Directory | [Uses]
2-amino-5-(2-fluorophenyl)-4-methyl-1H-pyrrole-3-carbonitrile (cas# 186033-14-7) is used as calcium-activated potassium channel (BKCa) activator for treating muscular disorder. | [in vivo]
NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1]. | Animal Model: | Rats[1] | | Dosage: | 1, 3 and 10 mg/kg | | Administration: | Intraduodenal administration, intravenous injection | | Result: | Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).
Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.
Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
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