| Identification | Back Directory | [Name]
MSI-1436 | [CAS]
186139-09-3 | [Synonyms]
MSI-1436
Trodusquemine
MSI-1436 USP/EP/BP
Trodusquemine (MSI-1436)
TRODUSQUEMINE;AMINOSTEROL-1436;MSI1436
Cholestane-7,24-diol, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)- | [Molecular Formula]
C37H72N4O5S | [MDL Number]
MFCD28386162 | [MOL File]
186139-09-3.mol | [Molecular Weight]
685.06 |
| Chemical Properties | Back Directory | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-3.49±0.18(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Treatment of medically significant obesity. | [Definition]
ChEBI: Trodusquemine is a bile acid. | [in vivo]
MSI-1436 (10 mg/kg, i.p.) causes obesity-dependent body weight, reduces total body fat content and adipocyte size and lipid content of white adipose tissue of mice. MSI-1436 treatment significantly reduces plasma insulin levels. MSI-1436 (10 mg/kg, i.p.) increases phosphorylation of STAT-3 2.7-fold and, in conjunction with 100 U/kg insulin, p-IRβ increases threefold over insulin alone-treated rats[1]. MSI-1436 (Trodusquemine) exhibits anxiolytic effect through a restoration of endocannabinoid (eCB) signaling within the amygdala[2]. MSI-1436 (5 mg/kg, i.p.) has an anti-diabetic effect on diabetic mice, and is sufficient to suppress food intake and cause weight loss in CD1 mice[3]. |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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