| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
1862212-48-3 | [Synonyms]
TH 1217
2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione | [Molecular Formula]
C20H17BCl2N4O6 | [MDL Number]
MFCD34470038 | [MOL File]
1862212-48-3.mol | [Molecular Weight]
491.09 |
| Hazard Information | Back Directory | [Uses]
TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. | [storage]
Store at -20°C | [References]
[1] Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148. DOI:10.1021/acs.jmedchem.5b01741
[2] Gordon DE, et, al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22; 2020.03.22.002386. DOI:10.1101/2020.03.22.002386 |
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| Company Name: |
BOC Sciences
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16314854226 |
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www.bocsci.com |
| Company Name: |
Wuhan Topule
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+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
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