| Identification | Back Directory | [Name]
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- | [CAS]
186299-00-3 | [Synonyms]
hCYP3A4 Fluorogenic substrate 1
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- | [Molecular Formula]
C19H12FNO2 | [MOL File]
186299-00-3.mol | [Molecular Weight]
305.3 |
| Chemical Properties | Back Directory | [Boiling point ]
492.4±28.0 °C(Predicted) | [density ]
1.392±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
-2.30±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
hCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 can be used for cell and in vivo imaging[1]. | [in vivo]
hCYP3A4 Fluorogenic substrate 1 (10 mg/kg; i.v.) can be used for imaging in vivo[1]. | Animal Model: | Male Sprague-Dawley rats[1] | | Dosage: | 10 mg/kg | | Administration: | I.v. | | Result: | Can be used as a probe substrate offers a highly efficient and easy-to-use approach for screening and characterizing hCYP3A4 inhibitors or time-dependent inactivators, which strongly facilitates hCYP3A4-mediated DDI studies. |
| [IC 50]
CYP3A4: 0.36 μM (Km) | [References]
[1] He RJ, et al. Rationally Engineered CYP3A4 Fluorogenic Substrates for Functional Imaging Analysis and Drug-Drug Interaction Studies. J Med Chem. 2023 May 25;66(10):6743-6755. DOI:10.1021/acs.jmedchem.3c00101 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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