| Identification | Back Directory | [Name]
DU-14 | [CAS]
186303-55-9 | [Synonyms]
DU-14
TETRADECANAMIDE, N-[2-[4-[(AMINOSULFONYL)OXY]PHENYL]ETHYL]- | [Molecular Formula]
C22H38N2O4S | [MDL Number]
MFCD19381840 | [MOL File]
186303-55-9.mol | [Molecular Weight]
426.61 |
| Chemical Properties | Back Directory | [density ]
1.089±0.06 g/cm3(Predicted) | [storage temp. ]
RT | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
solid | [pka]
8.74±0.70(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats.1 Inhibits proliferation of human MCF-7 breast cancer cells.2 | [Uses]
DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3]. | [in vivo]
DU-14 (30 mg/kg, i.p., once time) inhibits steroid sulfatase activity in both brain and liver tissues and enhances the memory-enhancing properties of DHEAS in rats with scopolamine-induced amnesia[2].
| [References]
1) Johnson et al. (2000), The effect of steroid sulfatase inhibition on learning and spatial memory; Brain Res., 865 286
2) Selcer et al. (1997), Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines; Cancer Res., 57 702 |
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