| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 3-[3-[4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-5-methyl- | [CAS]
186386-21-0 | [Synonyms]
Ro 70 0004,Ro700004
2,4(1H,3H)-Pyrimidinedione, 3-[3-[4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-5-methyl- | [Molecular Formula]
C20H24F4N4O3 | [MDL Number]
MFCD00954691 | [MOL File]
186386-21-0.mol | [Molecular Weight]
444.42 |
| Hazard Information | Back Directory | [Uses]
Ro 70-0004 (RS-100975) is a selective alpha1A-adrenoceptor antagonist with a pKi of 8.9. Ro 70‐0004 can be used in the study of prostatic hyperplasia[1]. | [IC 50]
Alpha-1A adrenergic receptor: 8.9 (pKi) | [References]
[1] Williams TJ, et al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8. DOI:10.1038/sj.bjp.0702541 |
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