| Chemical Properties | Back Directory | [Boiling point ]
650.5±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 25mg/mL, clear | [form ]
powder | [pka]
14.35±0.29(Predicted) | [color ]
white to beige | [InChIKey]
AUTGNDRENPBZKA-UXHICEINSA-N | [SMILES]
F[C@@H]1CN(C(CC2=CC=C(OC(F)(F)F)C=C2)=O)CC[C@@H]1OC3=C(C(N)=O)C=CC(OCC(C)(C)O)=C3 |
| Hazard Information | Back Directory | [Uses]
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with
IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. | [Biochem/physiol Actions]
PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor. | [IC 50]
TrkA: 7.7 nM (IC50, in cell-based assays); TrkB: 15 nM (IC50, in cell-based assays); TrkC: 3.9 nM (IC50, in cell-based assays) | [References]
[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633 |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|