| Identification | Back Directory | [Name]
Angiogenesis Inhibitor | [CAS]
186611-44-9 | [Synonyms]
Angiogenesis Inhibitor
Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem | [Molecular Formula]
C12H9N3O | [MOL File]
186611-44-9.mol | [Molecular Weight]
211.22 |
| Chemical Properties | Back Directory | [Melting point ]
228-230 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
572.7±50.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: 5mg/mL | [form ]
Yellow solid | [pka]
11.70±0.20(Predicted) | [color ]
yellow |
| Hazard Information | Back Directory | [Uses]
Angiogenesis Inhibitor is a cell-permeable indolinone. Anti-angiogenic activity. | [Definition]
ChEBI: 3-(1H-imidazol-5-ylmethylidene)-1H-indol-2-one is a member of indoles. | [General Description]
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 μM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 μM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 μM). | [Biochem/physiol Actions]
Cell permeable: yes |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|