| Identification | Back Directory | [Name]
Benzoic acid, 3-fluoro-4-hydroxy-, 1,1'-[1,3-phenylenebis(methylene)] ester | [CAS]
1867107-62-7 | [Synonyms]
RA-2 >=98% (HPLC)
Benzoic acid, 3-fluoro-4-hydroxy-, 1,1'-[1,3-phenylenebis(methylene)] ester | [Molecular Formula]
C22H16F2O6 | [MDL Number]
MFCD30480924 | [MOL File]
1867107-62-7.mol | [Molecular Weight]
414.36 |
| Chemical Properties | Back Directory | [Melting point ]
165-166 °C | [Boiling point ]
590.5±50.0 °C(Predicted) | [density ]
1.419±0.06 g/cm3(Predicted) | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [pka]
6.58±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
RA-2 is a pan-negative-gating modulator of KCa2/3 channels. It acts by inhibiting EDH-type relaxation in coronary arteries. | [Uses]
RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1]. | [storage]
Store at -20°C | [References]
[1] Oliván-Viguera A, et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015;87(2):338- DOI:10.1124/mol.114.095745 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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