| Identification | Back Directory | [Name]
A-893 | [CAS]
1868232-32-9 | [Synonyms]
A-893
CPD3627
(R)-N-Cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-hydroxy-2-(3-oxo-3,4-dihydro-2H-ben
N-cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[[(2R)-2-hydroxy-2-(3-oxo-4H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide
Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[(2R)-2-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-8-yl)-2-hydroxyethyl]amino]ethyl]- | [Molecular Formula]
C29H38Cl2N4O4 | [MDL Number]
MFCD28952792 | [MOL File]
1868232-32-9.mol | [Molecular Weight]
577.54 |
| Chemical Properties | Back Directory | [Boiling point ]
790.6±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.52±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM. | [IC 50]
SMYD2 | [References]
[1] Sweis RF, et al. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700. DOI:10.1021/acsmedchemlett.5b00124 |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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