| Identification | Back Directory | [Name]
2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE | [CAS]
186826-17-5 | [Synonyms]
ML 10302
Monohydrochloride (9CI)
2-PIPERIDINOETHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE
2-(Piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate | [Molecular Formula]
C15H21ClN2O3 | [MDL Number]
MFCD00931669 | [MOL File]
186826-17-5.mol | [Molecular Weight]
312.79 |
| Hazard Information | Back Directory | [Uses]
Potent, selective 5-HT4 serotonin receptor agonist. New ester of 4-Amino-5-chloro-2-methoxybenzoic acid as potent agonist and antagonist for 5-HT4 receptors. | [in vivo]
ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice[3].
| Animal Model: | 8-weeks old adult male C57BL/6j wild-type mice (23-27?g)[3] | | Dosage: | 5 mg/kg, 10 mg/kg, 20?mg/kg | | Administration: | Subcutaneous injection | | Result: | Significantly increased sAPPα level in the cortex. |
| [IC 50]
5-HT4 Receptor: 4 nM (EC50); 5-HT4 Receptor: 1.07 nM (Ki); 5-HT3 Receptor: 782 nM (Ki) |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|