| Identification | Back Directory | [Name]
NS309 | [CAS]
18711-16-5 | [Synonyms]
NS 309; NS-309
NS309;NS 309;NS-309
6,7-Dichloroisatin 3-oxime
6,7-Dichloroindole-2,3-dione 3-oxime
6,7-Dichloro-1H-indole-2,3-dione3-oxime
6,7-Dichloro-3-(hydroxyiMino)indolin-2-one
1H-Indole-2,3-dione,6,7-dichloro-, 3-oxiMe | [Molecular Formula]
C8H4Cl2N2O2 | [MDL Number]
MFCD06798346 | [MOL File]
18711-16-5.mol | [Molecular Weight]
231.04 |
| Chemical Properties | Back Directory | [Melting point ]
190-192℃ | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~22 mg/mL
| [form ]
solid
| [color ]
yellow
| [InChI]
1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13) | [InChIKey]
CVOUSAVHMDXCKG-UHFFFAOYSA-N | [SMILES]
O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12 |
| Hazard Information | Back Directory | [Uses]
NS 309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels. | [Biological Activity]
Positive modulator of small- and intermediate- conductance Ca 2+ -activated K + channels (SK and IK channels); increases Ca 2+ sensitivity. Displays no activity at BK channels. | [Biochem/physiol Actions]
NS309 is a Ca2+-activated IK/SK potassium channel activator. | [in vivo]
NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits[6].
| Animal Model: | Adult New Zealand white rabbits (2.5-3.0 kg)[6] | | Dosage: | 2 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Significantly improved neurological outcome of SCI/R challenged rabbits. |
| [storage]
+4°C |
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