| Identification | Back Directory | [Name]
1,1,1-Trifluoroethyl-PEG5-Tos | [CAS]
1872433-61-8 | [Synonyms]
1,1,1-Trifluoroethyl-PEG5-Tos
1,1,1-Trifluoroethyl-PEG4-Tos
3,6,9,12-Tetraoxatetradecan-1-ol, 14,14,14-trifluoro-, 1-(4-methylbenzenesulfonate) | [Molecular Formula]
C17H25F3O7S | [MDL Number]
MFCD29079383 | [MOL File]
1872433-61-8.mol | [Molecular Weight]
430.44 |
| Hazard Information | Back Directory | [Description]
1,1,1-Trifluoroethyl-PEG5-Tos has a trifluoroethyl and tosyl attached to it. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
1,1,1-Trifluoroethyl-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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