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1874276-76-2

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1874276-76-2 Structure

1874276-76-2 Structure
IdentificationBack Directory
[Name]

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
[CAS]

1874276-76-2
[Synonyms]

LXS-196
IDE-196
EOS-61826
NVP-LXS196
LXS196,IDE196
NVP-LXS196; NVPLXS196; NVP LXS196; LXS-196; LXS 196; LXS196; LXS-196
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
2-Pyrazinecarboxamide, 3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-
[Molecular Formula]

C22H23F3N8O
[MOL File]

1874276-76-2.mol
[Molecular Weight]

472.47
Chemical PropertiesBack Directory
[Boiling point ]

592.7±50.0 °C(Predicted)
[density ]

1.387±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
[form ]

A crystalline solid
[pka]

7.65±0.70(Predicted)
[color ]

Light yellow to yellow
[InChIKey]

XXJXHXJWQSCNPX-UHFFFAOYSA-N
[SMILES]

C1(C(NC2=NC=CC=C2N2CCC(N)(C)CC2)=O)=NC(C2=NC=CC=C2C(F)(F)F)=CN=C1N
Hazard InformationBack Directory
[Uses]

Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research[1][2].
[in vivo]

Darovasertib (LXS196; compound 9) (15, 30, 75, 150 mg/kg, P.O., mice) shows improved efficacy (regression) in a 92.1 GNAQ uveal melanoma xenograft model in a dose-dependently manner[2].

Animal Model:Mice implanted with 92.1 GNAQ mutant uveal melanoma cells[2].
Dosage:15, 30, 75, 150 mg/kg
Administration:P.O. (bid) for 35 days
Result:Dose-dependently suppressed the tumor growth.
[IC 50]

PKCα: 1.9 nM (IC50); PKCθ: 0.4 nM (IC50); GSK3β: 3.1 μM (IC50)
[storage]

Store at -20°C
[References]

[1] Protein Kinase C Inhibitor LXS196
[2] US20180179181.
Spectrum DetailBack Directory
[Spectrum Detail]

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide(1874276-76-2)1HNMR
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