| Identification | Back Directory | [Name]
BI8626 | [CAS]
1875036-75-1 | [Synonyms]
BI8626
BI8626
(BI-8626
1,3-Benzenedimethanamine, N1-[8-[4-(phenylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidin-4-yl]- | [Molecular Formula]
C25H28N8 | [MDL Number]
MFCD32062793 | [MOL File]
1875036-75-1.mol | [Molecular Weight]
440.54 |
| Chemical Properties | Back Directory | [Boiling point ]
654.4±55.0 °C(Predicted) | [density ]
1.302±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (189.15 mM; Need ultrasonic) | [form ]
Solid | [pka]
9.01±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM[1]. | [Biological Activity]
BI8626 is a specific antagonist of the ubiquitin ligase HUWE1 with IC50 of 0.9 μM. | [target]
| [storage]
Store at -20°C | [References]
[1] Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.EMBO Mol Med. 2014 Dec;6(12):1525-41. DOI:10.15252/emmm.201403927 |
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