| Identification | Back Directory | [Name]
5-nitrobenzofuran | [CAS]
18761-31-4 | [Synonyms]
5-nitrobenzofuran
Benzofuran, 5-nitro-
5-Nitro-[2,3]-benzofuran | [Molecular Formula]
C8H5NO3 | [MDL Number]
MFCD00456542 | [MOL File]
18761-31-4.mol | [Molecular Weight]
163.13 |
| Chemical Properties | Back Directory | [Melting point ]
114-115 °C | [Boiling point ]
273.1±13.0 °C(Predicted) | [density ]
1.380±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly) | [form ]
Solid | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Uses]
5-Nitro-1-benzofuran is a chemical reagent used in the synthesis of internal alkynes. Also used in the preparation of anti-oxidants quinolines. | [Synthesis]
Step 1c. Synthesis of 5-nitrobenzofuran (Compound 104): a mixture of (2-fluoro-5-nitrophenyl)ethynyltrimethylsilane (Compound 103, 7.30 g, 30.8 mmol), sodium acetate (10.1 g, 123 mmol), and N,N-dimethylformamide (70 mL) was stirred and reacted for 16 hours at 100 °C. After completion of the reaction, the precipitate was collected by filtration and washed with N,N-dimethylformamide. The filtrates were combined and the solvent was removed by evaporation to give the crude product. The crude product was purified by short silica gel column chromatography (eluent: ethyl acetate/petroleum ether=1/10) to afford the title compound 104 as a brown solid (3.0 g, 60% yield). | [References]
[1] Patent: US2009/76044, 2009, A1. Location in patent: Page/Page column 25 |
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