| Identification | Back Directory | [Name]
1-Azoniabicyclo[2.2.2]octane, 4-[[[[4-[3,5-bis(trifluoromethyl)phenyl]-1-(1H-indol-3-ylmethyl)-2-oxobutyl]amino]carbonyl]amino]-1-methyl-, bromide (1:1) | [CAS]
187724-86-3 | [Synonyms]
L743
L-743
L 743
L743310
L-743310
L 743310
1-Azoniabicyclo[2.2.2]octane, 4-[[[[4-[3,5-bis(trifluoromethyl)phenyl]-1-(1H-indol-3-ylmethyl)-2-oxobutyl]amino]carbonyl]amino]-1-methyl-, bromide (1:1) | [Molecular Formula]
C30H33BrF6N4O2 | [MOL File]
187724-86-3.mol | [Molecular Weight]
675.51 |
| Hazard Information | Back Directory | [Description]
L 743310 is a neurokinin-1 receptor antagonist. | [Uses]
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis[1]. | [References]
[1] Tachykinin NK1 Receptor Antagonists Act Centrally to Inhibit Ernesis Induced by the Chemotherapeutic Agent Cisplatin in Ferrets |
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