| Identification | Back Directory | [Name]
Benzamide, 4-[[4-[[4-chloro-3-[[(1,1-dimethylethyl)sulfonyl]amino]phenyl]amino]-5-methyl-2-pyrimidinyl]amino]-2-fluoro-N-(1-methyl-4-piperidinyl)- | [CAS]
1877286-78-6 | [Synonyms]
SG3-179
Benzamide, 4-[[4-[[4-chloro-3-[[(1,1-dimethylethyl)sulfonyl]amino]phenyl]amino]-5-methyl-2-pyrimidinyl]amino]-2-fluoro-N-(1-methyl-4-piperidinyl)- | [Molecular Formula]
C28H35ClFN7O3S | [MOL File]
1877286-78-6.mol | [Molecular Weight]
604.14 |
| Hazard Information | Back Directory | [Uses]
SG3-179 is a potent inhibitor against the BET bromodomain proteins. SG3-179 is also a JAK2 and FLT3 inhibitor. SG3-179 causes a rapid reduction in HOXB13 protein expression. SG3-179 is promising for research of multiple myeloma (MM1.S)[1][2]. | [References]
[1] Nerlakanti N, et al. Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2018 Dec;17(12):2796-2810. DOI:10.1158/1535-7163.MCT-18-0602
[2] Guan X. Discovery of Fluorescence Polarization Probes and Inhibitors for Testis-Specific Bromodomain and Extra-Terminal (BRDT) Proteins[J]. 2020. |
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