| Identification | Back Directory | [Name]
BOC-GLY-GLY-PHE-GLY-OH | [CAS]
187794-49-6 | [Synonyms]
GGFG
Boc-GGFG-OH
BOC-GLY-GLY-PHE-GLY-OH
N-[(1,1-Dimethylethoxy)carbonyl]glycylglycyl-L-phenylalanylglycine
Glycine, N-[(1,1-dimethylethoxy)carbonyl]glycylglycyl-L-phenylalanyl-
(S)-12-benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid
2-[[(2S)-2-[[2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid | [Molecular Formula]
C20H28N4O7 | [MDL Number]
MFCD02259478 | [MOL File]
187794-49-6.mol | [Molecular Weight]
436.46 |
| Chemical Properties | Back Directory | [Boiling point ]
838.6±65.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
DMSO : ≥ 100 mg/mL (229.12 mM)| | [form ]
Solid | [pka]
3.32±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : 25 mg/mL (57.28 mM; Need ultrasonic) | [Sequence]
Boc-Gly-Gly-Phe-Gly-OH | [InChIKey]
PTUJJIPXBJJLLV-AWEZNQCLSA-N | [SMILES]
C(O)(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Description]
Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). | [Uses]
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). | [IC 50]
Cleavable Linker | [References]
[1] Dernovics M, et al., Synthesis and application of a Sec2-containing oligopeptide for method evaluation purposes in selenium speciation. Talanta. 2012 Sep 15;99:186-93. DOI:10.1016/j.talanta.2012.05.038 |
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