| Identification | Back Directory | [Name]
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID | [CAS]
187949-90-2 | [Synonyms]
BUTTPARK 23\09-45
RARECHEM AL BO 0714
SALOR-INT L252034-1EA
5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC
5-Amino-1-(4-fluorophenyl)pyrazole-4-carboxylic Acid
5-amino-1-(4-fluorophenyl)-4-pyrazolecarboxylic acid
5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-fluorophenyl)-
5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole, 1-(5-Amino-4-carboxy-1H-pyrazol-1-yl)-4-fluorobenzene | [Molecular Formula]
C10H8FN3O2 | [MDL Number]
MFCD01569434 | [MOL File]
187949-90-2.mol | [Molecular Weight]
221.19 |
| Hazard Information | Back Directory | [Synthesis]
mmol) in a solvent mixture of methanol (200 mL). The reaction mixture was heated to reflux for 17 h, followed by cooling to room temperature and filtration. The filtrate was acidified with 2 N HCl solution to pH=7. The precipitated solid was collected by filtration and dried under reduced pressure to afford the target compound 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid as a light yellow solid (18.64 g, 95% yield), which was used in subsequent reactions without further purification. | [References]
[1] Patent: WO2008/53136, 2008, A1. Location in patent: Page/Page column 36
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5032 - 5038
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 5, p. 1562 - 1575
[4] Patent: WO2008/74814, 2008, A1. Location in patent: Page/Page column 56
[5] Patent: WO2008/777, 2008, A2. Location in patent: Page/Page column 58-59 |
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