| Identification | Back Directory | [Name]
CORYNOLINE | [CAS]
18797-79-0 | [Synonyms]
CORYNOLINE
CORYNOLINE(P)
(+)-Corynoline
dimethyl-, (5bR,6S,12bR)-
13-Methylchelidonan-11β-ol
Corynoline, 98%, from Corydalis bungeana Turcz.
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol,5b,6,7,12b,13,14-hexahydro-5b,13-
(5bR)-5bα,13-Dimethyl-5bα,6,7,12bα,13,14-hexahydro[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-6β-ol
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)- | [Molecular Formula]
C21H21NO5 | [MDL Number]
MFCD11042250 | [MOL File]
18797-79-0.mol | [Molecular Weight]
367.4 |
| Chemical Properties | Back Directory | [Melting point ]
180～181℃ | [Boiling point ]
504.2±50.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly, Heated) | [form ]
Solid | [pka]
14.14±0.40(Predicted) | [color ]
Off-White to Pale Yellow | [Stability:]
Light Sensitive | [InChI]
InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1 | [InChIKey]
IQUGPRHKZNCHGC-TYPHKJRUSA-N | [SMILES]
[C@@H]1(O)[C@@]2(C)[C@]([H])(N(C)CC3=C2C=CC2OCOC3=2)C2C=C3OCOC3=CC=2C1 |
| Hazard Information | Back Directory | [Description]
The empirical formula of corynoline should read C21H21NO5 | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from bitter herb. | [Uses]
Corynoline is an isoquinoline alkaloid with reported pharmacological activity such as cell adhesion inhibition, sedation and liver protection. | [Definition]
ChEBI: A benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotec
ive activity. |
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