| Identification | Back Directory | [Name]
I-BET 151 hydrochloride | [CAS]
1883545-47-8 | [Synonyms]
I-BET 151 hydrochloride
I-BET 151 dihydrochloride
7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride | [Molecular Formula]
C23H22ClN5O3 | [MDL Number]
MFCD30182237 | [MOL File]
1883545-47-8.mol | [Molecular Weight]
451.91 |
| Hazard Information | Back Directory | [Biological Activity]
i-bet 151 dihydrochloride is a bet bromodomain inhibitor that prevents bet from recruiting to chromatin. i-bet 151 induces mll-fusion leukemia cell line apoptosis and g0 / g1 cell cycle arrest in vitro, and reduces bcl2 expression in nomo1 cells. i-bet 151 improves the survival rate of two kinds of mll fusion leukemia mice, and enhances the differentiation of human ipscs into megakaryocytes.[1]. malherbe p, masciadri r, norcross r d, et al. characterization of (r,s)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3h-benzofuran-2-one as a positive allosteric modulator of gabab receptors. british journal of pharmacology, 2008, 154(4): 797. | [storage]
-20°C |
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