| Identification | Back Directory | [Name]
1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate | [CAS]
1883548-85-3 | [Synonyms]
WAY 181187 oxalate
1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate | [Molecular Formula]
C17H15ClN4O6S2 | [MDL Number]
MFCD30182323 | [MOL File]
1883548-85-3.mol | [Molecular Weight]
470.907 |
| Hazard Information | Back Directory | [Uses]
WAY 181187 Oxalate is a high affinity and selective 5-HT6 agonist. It displays 60-fold selectivity over other 5-HT and monoamine receptors and increases firing rate of 5-HT neurons. | [in vivo]
Acute administration of WAY-181187 (SAX-187) oxalate (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 oxalate (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels[1]. | [IC 50]
5-HT6 Receptor: 2.2 nM (Ki); 5-HT6 Receptor: 6.6 nM (EC50) | [storage]
Store at -20°C |
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BOC Sciences
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https://www.bocsci.com |
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