1883730-99-1

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1883730-99-1 Structure

Chemical Properties	Back Directory
[Melting point ] 170 °C
[Boiling point ] 701.9±60.0 °C(Predicted)
[density ] 1.51±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ] Solid
[pka] 14.78±0.10(Predicted)
[color ] Deep purple to brown

Hazard Information	Back Directory
[Uses] LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs[1].
[IC 50] Topoisomerase I; Topoisomerase II
[References] [1] Marzi L, et al. The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2. Mol Cancer Ther. 2020 Aug;19(8):1589-1597. DOI:10.1158/1535-7163.MCT-19-1064

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