| Chemical Properties | Back Directory | [Boiling point ]
2946.916±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.327±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [color ]
White to off-white | [Sequence]
Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2 |
| Hazard Information | Back Directory | [Uses]
human GIP(3-30), amide is a high affinity antagonist of the human GIP receptor in vitro[1]. | [References]
[1] Sparre-Ulrich AH, et al. GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release. Biochem Pharmacol. 2017;131:78-88. DOI:10.1016/j.bcp.2017.02.012
[2] Gabe MBN, et al., Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors. Biochem Pharmacol. 2018 Apr;150:97-107. DOI:10.1016/j.bcp.2018.01.040 |
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