| Identification | Back Directory | [Name]
HDAC8-IN-20a | [CAS]
1884231-52-0 | [Synonyms]
HDAC8-IN-20a
HDAC8 inhibitor 20a
HDAC8 inhibitor-20a
Benzamide, N-hydroxy-4-methoxy-3-(phenylmethoxy)- | [Molecular Formula]
C15H15NO4 | [MOL File]
1884231-52-0.mol | [Molecular Weight]
273.28 |
| Hazard Information | Back Directory | [Description]
HDAC8-IN-20a is a potent and selective HDAC8 inhibitor. | [Uses]
HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC50 values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC50 values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research[1]. | [IC 50]
hHDAC8: 23.9 μM (IC50); smHDAC8: 268.2 μM (IC50); hHDAC1: 12.1 μM (IC50); hHDAC6: 2.9 μM (IC50) | [References]
[1] Heimburg T, et al. Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem. 2016 Mar 24;59(6):2423-35. DOI:10.1021/acs.jmedchem.5b01478 |
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